GROWTH AND ENZYMATIC ACTIVITIES OF VITAMIN B6 ANALOGUES

GROWTH AND ENZYMATIC ACTIVITIES OF VITAMIN Bg ANALOGUES

Enzymatic phosphorylation of vitamin B6 analogues and their effect on tyrosine decarboxylase.

Structural analogues of naturally occurring compounds may exert inhibitory action by direct competition or they may be metabolized to form inhibitory compounds (2). In the case of the vitamin Bg antagonist, deoxypyridoxine, Umbreit and Waddell (3) have shown that this compound must be phosphorylated before it becomes an inhibitor of tyrosine apodecarboxylase. It is of interest that arabitylflav...

Renal glutaminase activities in vitamin B6-deficient rats.

Glutamine has been implicated in the functioning of the central nervous system (l), in muscle metabolism (a), in transamination (3), in detoxification (4), and as a precursor of urinary ammonia (5). An excellent review of these and other possible r&es of glutamine in metabolism has been presented by Archibald (6). It would seem that glutamine acts as a mobile reserve of ammonia and glutamic aci...

Vitamin B6 and arteriosclerosis.

In 1949, Rinehart and Greenberg reported that marked arteriosclerosis occurs in vitamin-B6-deficient monkeys. The present study investigates the relationship between vitamin B6 and arteriosclerosis and summarizes the results. I found that thrombogenesis, disorder of collagen metabolism and production of free radicals may be the processes that cause arteriosclerosis in human and experimental ani...

The effect of vitamin B6 on growth of tumor.

Attempts have been made to clarify the effect of pyridoxine deficiency as well as its overdosis on growth of transplantable tumors in mouse and rat. The growth of transplantable solid tumor in pyridoxine deficient animals was remarkably suppressed while that of ascites tumor was not. The tumor bearing host was administered with a large amounts of pyridoxine and pyridoxal phosphate resulting in ...